D. Wu

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

The paper reviews dose-response models and introduces MOSAIC, a tool for environmental risk assessment using TKTD models to improve pesticide risk evaluation for aquatic organisms.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This paper demonstrates that mass photometry can rapidly and accurately characterize rAAV vectors by resolving capsid populations and quantifying full and empty capsids.

This study investigates how SARS-CoV-2 N-protein interacts with nucleic acids to form supramolecular clusters and phase-separated droplets, revealing structural and energetic changes during assembly.

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

The paper reanalyzes a single-cell RNA-Seq dataset to identify cellular and molecular differences in severe versus mild COVID-19, suggesting potential biomarkers for disease severity.

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

The paper identifies bile acid metabolizing microbes and genes associated with NAFLD subtypes using metagenomic data and develops a classifier model for NAFLD detection.

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

This paper assesses how uncertainty in ER50 values affects HR5 estimates in SSD analyses for non-target plants using Bayesian and frequentist methods.

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This paper introduces a flow-cell based system for high-throughput characterization of base-modified DNA aptamers using a modified Illumina MiSeq instrument.

This study uses mass spectrometry to show that the stability of DC-SIGN is better correlated with the number of glycosylation sites than with glycan mass or length.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study uses methylene blue for NIR-II fluorescence imaging to enable structural and functional imaging of the urinary system in vivo and preclinical renal function assessment.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.