D. Yang

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

The paper develops and validates force field parameters for fluorinated amino acids in the AMBER ff15ipq force field, enabling accurate MD simulations of fluorinated proteins and validating them with experimental NMR data.

This paper investigates how different methods for measuring stem embolism vulnerability affect results, finding that nano-particles may induce early cavitation and that the origin of these particles might be from living cells near vessels.

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

The paper derives an analytical solution for root pressure and applies it to a 7-meter bamboo shoot's hydraulic architecture.

This study investigates the biocompatibility of single-walled carbon nanotubes in plants, finding that surface chemistry determines toxicity and cellular response.

This study develops a reliable alveolar type 2 organoid platform to model diverse genetic subtypes of lung adenocarcinoma in vitro and in vivo.

This study shows that C. elegans vertically transmits gut bacteria to offspring, which colonize tissues during development and influence immunity.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

The paper identifies a Klebsiella strain from the gut of Spodoptera frugiperda larvae that degrades PVC, using multi-omics to characterize the degradation pathway.

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.