D. Zhang

This paper introduces a nonlinear FEM framework in Matlab for analyzing and optimizing bio-inspired compliant mechanisms in medical applications, showing its accuracy through simulations and experiments.

This paper introduces an enzymatic RNA biotinylation method to identify RNA-protein interactions and enrich RNA in mammalian cells, demonstrating its utility in identifying binding partners of 7SK snRNA and HOTAIR.

This study identifies 24 putative ORI events in crustacean mitochondrial genomes, showing that inversion events and gene strand switches can create mutational biases affecting phylogenetic and evolutionary analyses.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This paper demonstrates sequential optical activation of two mRNAs in the same cell using photo-cages, enabling precise control of translation with single-cell resolution.

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

This study identifies novel Ig domain proteins in SARS-related coronaviruses, highlighting their rapid evolution and potential role in pathogenesis.

This study shows that exosomes from SVV-infected cells can carry and transmit SVV between susceptible and non-susceptible cells, and this transmission is resistant to neutralizing antibodies.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.

This study identifies adaptive divergence followed by population admixture as a source of additive genetic variance in evolutionarily important traits, showing a strong positive correlation between heritability and evolutionary importance.

The paper identifies CK2 interacting proteins in M. oryzae and shows CK2 correlates with phosphatases and disaggregases, suggesting a role in protein aggregation and RNA/DNA binding.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

The paper shows Ctf4 organizes sister replisomes and Pol alpha into a replication factory by dimerizing CMG helicase and binding one Pol-primase.

The paper describes a hybrid DNA structure combining G-quadruplex and i-motif elements, revealing new structural diversity in DNA.

The paper reports the cryo-EM structure of the eukaryotic CMG helicase on forked DNA, revealing a 'dam-and-diversion tunnel' mechanism for DNA unwinding.

The paper introduces VHUT-cryo-FIB, a workflow for preparing frozen-hydrated tissue lamella for cryo-ET, and demonstrates its effectiveness using rat and spinach samples.

This study examines how melatonin affects wheat seed germination and amino acid content under PEG stress, finding that 300 μM melatonin improves germination metrics and lysine levels.

The paper uses solid-state NMR to study a constitutively open mutant of KcsA, finding reduced potassium binding affinity at the selectivity filter, supporting allosteric coupling in C-type inactivation.

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This study investigates the localization and role of CK2 in Magnaporthe oryzae during growth and infection, finding it localizes to nuclei, nucleoli, septal pores, and appressoria with regulatory functions.

The paper investigates how mitochondrial architecture rearrangements in Isopoda cause asymmetrical mutational pressures, leading to unreliable phylogenetic reconstructions and supports Asellota as the basal isopod branch.

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

The paper introduces TmDOTP, an NMR thermometer for monitoring temperature in solid-state NMR experiments, showing it provides higher thermal sensitivity and resolution than traditional methods.

This study examines how food restriction affects tree shrews' body mass, energy metabolism, and thermogenesis under different temperatures and food intake levels.