H. Chen

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

PeerPub enables multiple rats to self-administer solutions concurrently, showing increased consumption in group housing compared to isolation.

This study shows how Cbf1's HLH region interacts with histones to slow nucleosome dissociation, enabling chromatin opening.

This study analyzes gene mutations in CHIKV E1 and E2 proteins from 2014 to 2019, identifying common mutation sites and their potential impact on immune escape and serological detection.

The paper reanalyzes ancient whole-genome duplication events in leptosporangiate ferns using phylogenetic methods and substitution rate corrections, identifying four WGDs and highlighting methodological uncertainties.

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This paper develops a BSMV-mediated gene editing system for wheat to improve FHB resistance by editing the Fhb1 gene without requiring transformation.

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

SAI automates stomatal parameter quantification on microscope images, achieving results consistent with human experts and improving efficiency in plant physiology research.

This paper identifies a novel daidzein reductase gene C1-07020 from Clostridium C1 that exhibits bidirectional enzyme activity and is widely distributed in human and animal gut microbiomes, offering new insights into (S)-equol production and potential applications.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

This study examines the effects of knocking out LHCB1 in Arabidopsis thaliana, showing reduced chlorophyll levels, altered photosystem absorption, and changes in thylakoid structure.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

The paper identifies CDRH3 loops in the naive B cell receptor repertoire that can be engaged by candidate immunogens using a combined experimental and computational approach.

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

This study introduces a transparent ultrasound transducer as a cranial window for multimodal imaging of awake mouse brains.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

This paper engineers RNA viruses with an unnatural amino acid to create adjustable immune responses in mice, demonstrating potential for vaccine development.

This paper presents a method using unnatural amino acid-engineered drug-resistant influenza virus to sterilize drug-resistant strains, validated in vitro and in animal models.