H. Chen

This study shows that ultrasound with microbubbles can enhance glymphatic transport in mouse brains by mechanically stimulating perivascular fluid movement.

This study demonstrates that TRPV1-mediated sonogenetics can safely modulate motor cortex activity in mice, inducing behavioral changes without significant tissue damage.

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

This study identifies AhR as a barrier to HIV-1 infection and outgrowth in Th17-polarized CD4+ T-cells and suggests AhR inhibitors could enhance viral outgrowth in HIV-1 cure strategies.

This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.

This study identifies TRAF6 as a regulator of PD-L1 expression in melanoma through YAP1-TFCP2 signaling, showing TRAF6 inhibition enhances anti-tumor immunity.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This paper introduces a new vaccine evaluation system based on pathogen clearance and liver trapping to assess immunoprotective potential against bacterial infections.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

This paper introduces ONE microscopy, a technique that enables nanoscale imaging of single proteins and molecular complexes, revealing structural details in cells and disease samples.

This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.

The paper introduces a workflow for quantifying IgG glycoforms using stable isotope labeled standards and LC-MS/MS-PRM, achieving high sensitivity and precision.

This study analyzes blood microbiome data from 9,770 healthy humans and finds no evidence of a common or consistent blood microbiome.

The paper identifies a bacterial gene cluster that compensates for human uricase loss by degrading uric acid in the gut, linking gut microbiota to hyperuricemia and gout risk.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study identifies TaHRC as a susceptibility gene for FHB in wheat, showing it suppresses calcium-mediated immune responses by interacting with TaCAXIP4.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

This study shows that FBXO11 deficiency in mice leads to impaired lung development and worsens cigarette smoke-induced airway fibrosis by promoting epithelial-mesenchymal transition.

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

This paper identifies VipR as an autoregulated transcription factor that activates vip3A gene expression during stationary phase in Bacillus thuringiensis, independent of sporulation.

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

This study shows that hypoxia suppresses pyruvate carboxylase (PC) in tumors, leading to increased lactate production and immunosuppression in the tumor microenvironment.