H. Lu

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study examines microbiome changes in lung and gut of NSCLC patients and finds sputum microbiota better predicts disease and metastasis than gut microbiota, with machine learning models achieving 0.842 AUC.

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

This paper develops a split-nCas9 system using intein-mediated reassembly for efficient base editing in plants.

This study investigates benzothiadiazine interactions with zwitterionic phospholipid membranes using molecular dynamics simulations to understand its behavior and binding mechanisms.

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

The paper develops a computational framework using Molecular Dynamics and Metadynamics to predict conformational variability of G12D mutated KRas-4B proteins at cell membranes, identifying druggable pockets for inhibitor design.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

This study uses FRET imaging in C. elegans to show stretch-induced conformational changes in twitchin kinase during muscle activity.

This paper applies Faster R-CNN to track C. elegans behavior across different life stages and conditions, demonstrating its flexibility and scalability for large-scale studies.

This study identifies FLK as a regulator of pathogen defense in Arabidopsis, showing it affects resistance to bacterial and fungal pathogens through modulation of defense signaling and ROS scavenging.

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.

This paper introduces a surface-coating technique to improve DNA sequencing speed, cost, and throughput for genomic applications.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

The paper identifies a long-lasting salt bridge as the key mechanism anchoring oncogenic KRas-4B to cell membranes through all-atom simulations.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.