J. Du

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

This study identifies two molecular subtypes of gastric cancer using multi-omics data and clustering algorithms, showing distinct survival outcomes and therapeutic responses.

High copper availability represses SPL7, releasing its suppression on key ABA biosynthetic genes and leading to increased ABA accumulation that inhibits growth but enhances drought tolerance.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

This study uses molecular dynamics simulations to model how EndoS2 interacts with IgG, revealing structural insights into its substrate recognition and catalytic mechanism.

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

This paper reports cryo-EM structures of TRPM5 channels in different states, revealing mechanisms of activation and inhibition through ligand binding sites.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

The paper identifies a mechanism by which H3K27me3 is recognized and transcriptionally repressed through the BAH-PHD-CPL2 complex in Arabidopsis.

This study identifies three intracellular residues that modulate TRPM3 channel activity through pH sensitivity, revealing their role in proton-induced inhibition and channel gating.

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

This paper develops a molecular clamping assay called ColoScape for early colorectal cancer detection using XNA-mediated qPCR, showing high sensitivity and specificity in clinical samples.

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study identifies UCH37 as a debranching deubiquitinase that promotes proteasomal degradation by cleaving K48 branched ubiquitin chains.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This study identifies AGTR1 as an overexpressed target in neuroendocrine neoplasms, showing its role in secretion and potential for imaging and therapy.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study shows mast cells contribute to fibrosis and effector cell recruitment in dermal chronic GVHD, suggesting they are potential therapeutic targets.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This study identifies NADP+ and NADPH as substrates of the circadian protein Nocturnin, showing its enzymatic activity in converting these metabolites and revealing structural insights into its mechanism.

The paper presents the crystal structure of the human Nocturnin catalytic domain and identifies structural differences from related deadenylases.

This study isolates and characterizes Bacillus amyloliquefaciens subsp. plantarum XH-9, showing it promotes plant growth and suppresses Fusarium oxysporum in wheat.