J. Wang

This paper investigates the triple-action inhibitory mechanism of deucravacitinib on TYK2, revealing its inhibition in three distinct states and structural basis for selectivity.

This study investigates how C. elegans modulates its avoidance response to hydrogen sulfide through environmental and internal factors, revealing HIF-1 signaling and ROS dynamics as key regulators.

The paper develops a portable paper-based LAMP biosensor for rapid on-farm detection of fecal contamination using Bacteroidales as a biomarker, achieving 100% concordance with lab tests.

This paper introduces ProteinMPNN, a deep learning model that improves protein expression, stability, and function by incorporating evolutionary and structural information.

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

This study identifies ARF6-dependent endocytic trafficking of the IFN-gamma receptor as a mechanism driving adaptive immune resistance in cancer, linking it to immune checkpoint blockade efficacy.

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

This study identifies a diverse range of viruses in oil reservoirs and their ecological roles in regulating microbial communities and biogeochemical cycles.

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

This study introduces a KitV834M mutant rat model that supports HSC engraftment without irradiation, offering a larger-scale alternative to mouse models for HSC research.

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

This study shows that growth deficiency and enhanced basal immunity in Arabidopsis mutants are genetically and functionally linked through shared regulatory pathways.

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

This study identifies anti-EEF1D autoantibodies in two patients with autoimmune cerebellar ataxia, suggesting their potential as a biomarker for diagnosis and recurrence prevention.

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

The paper screens 140 chlamydial antigens in mice to find subunit vaccine candidates, finding none effective but identifying pathogenic antigens and showing viable organisms induce better immunity.

The paper identifies DNA methylation changes in sepsis-induced monocyte dysregulation and shows these can be reversed with specific treatments.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

This study shows that HIV-positive older adults have a unique inflammatory response to Dectin-1 stimulation, marked by increased cytokines and immune activation.

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

The paper uses long-read sequencing to obtain complete metagenome-assembled genomes of anammox bacteria, revealing functional divergence and adaptive evolution through horizontal gene transfer and mobile genetic elements.