J. Wang

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study identifies CPSF3 as a druggable target in pancreatic cancer by showing its inhibition disrupts histone processing and cell proliferation.

This study shows that AtSWEET13 and AtSWEET14 transport sucrose, not GA, which is critical for pollen viability and germination during late anther development.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

The paper investigates how mechanical communication between cells leads to directional migration and branching connections, mediated by calcium channels, integrin β1, and N-cadherin.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This study identifies SOX15's role in maintaining pluripotency and promoting neural differentiation by interacting with coactivators and activating Hes5.

This study engineers a relaxin-2 variant with a longer serum half-life by fusing it with an antibody Fc fragment, maintaining RXFP1 agonist activity in vitro and in vivo.

This study shows that glycosylphosphatidylinositol-anchored MUC1 epitope pillars enhance chimeric antigen receptor T cell stimulation, with tandem repeat sequences showing greater activity.

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

This study shows that knocking out the Angiotensin II Type 1a Receptor in rats reduces high-fat diet-induced obesity by enhancing adipose lipolysis through the cAMP/PKA pathway.

This study analyzes AlphaFold-predicted protein structures across organisms to show that higher complexity correlates with specific structural and dynamic properties and statistical structural proximity reflecting phylogenetic relationships.

The paper identifies PEP7 as a ligand for the receptor kinase SIRK1, showing it regulates aquaporins and root growth through phosphorylation and water influx.

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

This study validates and invalidates SARS-CoV-2 main protease inhibitors using cell-based and cell-free assays, showing most repurposed drugs are not specific to Mpro.

This paper introduces a new histologic grading system for murine knee osteoarthritis that scores the entire joint, showing high reproducibility and sensitivity for detecting OA progression.

This paper demonstrates that integrating piezoelectric boron nitride nanotubes into muscle-based bio-bots improves their force output and motion speed.

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

The paper uses Oxford Nanopore sequencing to generate six gastropod mitochondrial genomes as part of a biodiversity curriculum, demonstrating its utility for hands-on genomics training.