J. Wang

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

This study quantitatively maps yeast cell fate decisions in response to pheromone by integrating experimental observations with theoretical models and stochastic simulations.

This study analyzes genomic diversity in Asian white birch to identify signals of adaptation and hybridization, finding 7,609 SNPs associated with environmental variables and highlighting climate change risks.

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study shows that vitamin D deficiency worsens lung inflammation during H1N1 and SARS-CoV-2 infections, while sufficient vitamin D reduces inflammation, though not viral replication.

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

This study shows that soluble amyloid-β oligomers trigger α-synuclein aggregation via heterogeneous primary nucleation, forming fibrils with α-synuclein cores and associated amyloid-β.

This study shows that helper NLR NRG1 forms oligomeric complexes with EDS1 and SAG101 at the plasma membrane upon co-activation of intracellular and cell surface receptors.

This study combines transcriptome and metabolome analysis to identify molecular responses of Desmodesmus sp. to sewage treatment, revealing key pathways and metabolite changes.

The paper uses single-channel electrophysiology to monitor TolC-AcrA complex formation and assesses inhibitor interactions through current and noise analysis.

This study identifies a water-soluble fraction of royal jelly that reduces squalene epoxidase expression in liver cells, thereby lowering cholesterol levels.

The paper uses a non-equilibrium landscape and flux approach to analyze a biophysically based model of decision-making and working memory, revealing trade-offs and mechanisms for improved performance.

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

The paper shows that topological defects in cellular swirl patterns predict cartilage differentiation potential of mesenchymal stromal cells.

This study analyzes the genetic diversity and evolution of two transmissible cancers in Tasmanian devils, revealing their emergence dates, mutation rates, and evolutionary patterns.

This study shows that the LRR domain of NLRP3 is essential for its inflammasome activation in macrophages by enabling self-association, oligomerization, and interaction with NEK7.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This study designs SARS-CoV-2 vaccines targeting conserved spike protein regions to reduce mutation escape, using epitope grafting on diverse scaffolds and showing immune response and diagnostic utility.

This study examines ICOS expression in gliomas using transcriptome data and clinical information, finding it correlates with malignancy, immune response, and poor prognosis.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This study identifies TNF-IR up-regulated and down-regulated modules in IBD patients and shows that upadacitinib and risankizumab reduce TNF-IR up-regulated mechanisms in JAK1 responders.

The paper investigates the toxic effects of elevated maternal bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy, finding that neonatal cardiac parameters correlate with maternal bile acid levels but show recovery in older neonates.

This paper introduces a neural network that predicts 3D RNA structure from sequence using Euclidean distance matrices, achieving high accuracy and speed.