J. Zhu

This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.

The paper investigates how mechanical torque influences mitotic spindle bipolarity by modeling centrosome interactions and showing torque promotes stable bipolar configurations.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study identifies and characterizes CLso effectors, showing diverse subcellular localization, expression patterns, and limited ability to suppress plant immune responses.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

This study uses CRISPR/Cas9 ribonucleoproteins delivered via particle bombardment to edit the wheat genome, resulting in a 10% reduction in culm length without yield loss.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

The paper identifies ubiquitin variants that inhibit Ube2k by binding to a hydrophobic cleft, blocking ubiquitin transfer and enzyme activation.

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

This study examines how temperature affects the behavior and molecular responses of Neptunea cumingii, showing significant physiological and transcriptomic changes outside the optimal temperature range of 8–16°C.

The paper uses CRISPR-Cas9 tiling screens to identify functional domains in human mitotic proteins, revealing new regions essential for cell proliferation and chromosome segregation.

This paper develops a nanomedicine approach to restore PLPP3 in endothelial cells, reducing YAP/TAZ activity and atherosclerosis in mice.

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

This paper develops a CRISPR-engineered bacteriophage T4 nanoparticle platform to create multiplex SARS-CoV-2 vaccine candidates, showing potent immune responses and protection in animal models.

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.

This study shows Synaptojanin1 deficiency increases basal autophagosome formation in astrocytes, with implications for Parkinsonism.

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.