J. Zhu

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.

This paper identifies key parameters and stages for all-aqueous printing of viscoelastic droplets in yield-stress fluids, providing a framework for precise 3D bioprinting.

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

This study shows that cell surface excess (CSE) is crucial for protrusions and motility in 3D collagen matrices, with microtubules regulating its storage and release.

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

This study identifies TWD1 as an ER-actin adapter that links myosin XI-K to auxin transport, explaining defects in ABCB biogenesis and plant development.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

Glycan trimming of HIV-1 Env immunogens improves vaccine-induced neutralizing antibody responses in small animals and primates.

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

The paper presents Cryo-EM structures of BK channels with Ba2+ ions, showing Ba2+ blocks the channel by occupying the selectivity filter and also binds to Ca2+ sites, with intermediate configurations observed.

This study shows that SMAD4 suppresses colitis-associated colon cancer by inhibiting CCL20/CCR6-mediated inflammation in mice.

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

This study identifies AFAP as a bacterial protein that enhances cell adhesion by interacting with host nucleolin, providing insights into the mechanism of A. phagocytophilum-induced cell adhesion in HGA.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

This paper develops a bacteriophage-based mucosal vaccine that induces strong immune responses and protects against SARS-CoV-2 and its variants without requiring needles or adjuvants.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.