L. Zhang

The paper identifies a mechanism by which H3K27me3 is recognized and transcriptionally repressed through the BAH-PHD-CPL2 complex in Arabidopsis.

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

This study identifies a leucine-derived fatty acid and glycosphingolipid that mediate amino acid sensing by mTORC1 in C. elegans, regulating development through protein translation and ribosomal biogenesis.

This study develops upconversion nanoparticles to monitor mitochondrial temperature dynamics in living cells and shows distinct thermal responses to various stimuli.

This study develops mEnv liposomes (MELs) as a vaccine platform that elicits HIV broadly neutralizing antibodies without extra proteins, showing neutralization of tier 2 HIV isolates in rabbits.

The paper compares the D614G mutation in SARS-CoV-2 spike protein, finding it reduces S1 shedding and increases infectivity without affecting ACE2 binding or neutralization.

This study identifies the EDS1-PAD4-ADR1 node as a convergence point for immune signaling in Arabidopsis, linking surface and intracellular LRR receptors.

This paper shows that an engineered RBD with glycosylation sites improves immunogenicity and expression efficiency in SARS-CoV-2 vaccines.

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

This study identifies RBM39's role in promoting PRRSV proliferation by altering c-Jun phosphorylation and binding viral RNA.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

The paper withdraws due to potential data analysis artefacts affecting conclusions about functional structure and ecosystem multifunctionality.

The paper models the 2019-nCov epidemic in China, finding comparable transmissibility but lower fatality rates than SARS and MERS, and highlights the impact of early interventions.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study shows that laccase genes are essential for root development and phenolic acid metabolism in Salvia miltiorrhiza using CRISPR/Cas9 gene knockout.

The paper shows that measles viruses cannot evolve to escape vaccine-induced neutralizing antibodies due to constraints on antigenic sites.

The paper systematically characterizes adhesins in Candida albicans and identifies genetic interactions affecting virulence using a CRISPR-based mutant library and C. elegans model.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study shows that intermittent anti-PI3K treatment can overcome immune checkpoint therapy resistance in Pten-null prostate cancer by converting 'cold' tumors into T cell-inflamed ones.

This study develops a photochemical probe to identify the small-molecule binding site in HHAT, leading to the discovery of a potent inhibitor and insights into MBOAT inhibition mechanisms.

This study shows arachidonic acid metabolism regulates macrophage polarization by affecting oxidative phosphorylation through PPARG, influencing M1 and M2 macrophage activation.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

The paper identifies a novel enzyme, MurG2, that can substitute for the essential MurG enzyme in Lipid II synthesis across different bacterial genera.

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

This study identifies MCAD as a critical enzyme for fatty acid metabolism in GBM, showing its essential role in preventing mitochondrial damage and apoptosis.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.