P. Chen

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This paper introduces a new fluorescent marker, PKMO, enabling 3D live-cell STED nanoscopy of mitochondria with improved photostability and reduced phototoxicity, allowing multiplexed imaging of mitochondrial dynamics and interactions.

The paper identifies YAB11-NGAL1 as a regulator of leaf serration in poplar through GWAS and eQTN mapping, showing its role in environmental adaptation and morphological plasticity.

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

This study modifies lattice lightsheet microscopy to enable optogenetic manipulation of cell migration with high spatiotemporal resolution, achieving subcellular control and long-term cell viability.

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

This study describes a cryobanking method that preserves phenotypic and functional characteristics of human distal lung epithelial cells, including alveolar type 2 pneumocytes.

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

The paper maps the topology of IpaB in Shigella translocons and shows its role in forming the pore channel for virulence protein delivery.

This study identifies a pyroptosis-related molecular classification and prognostic signature for glioma using integrative analysis of genomic and clinical data.

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

This study shows that strain gradients can drive directional cell migration in rat embryonic fibroblasts, distinct from durotaxis or haptotaxis.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This study shows actin polymerization is required for T3SS translocon pore opening, enabling effector translocation, but not for docking or membrane insertion.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

This study tracks immune responses in hospitalized COVID-19 patients up to 9 months post-infection, showing persistent neutralizing antibodies and memory B and T cells.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

The paper identifies increased levels of specific non-HLA autoantibodies in kidney transplant patients with antibody-mediated rejection.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.