S. Li

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

This paper shows IL-38 promotes intestinal stem cell growth by enhancing WNT signaling and beneficial IL-1beta secretion, while also having anti-inflammatory effects in the small intestine.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

This paper introduces a one-step genome editing method for high-efficiency homozygous tagging of endogenous proteins with auxin-inducible degron in human cells, achieving >80% efficiency in A431 cells and >50% in H9 ES cells.

This paper develops a whole-cell bioelectronic sensor using Lactiplantibacillus plantarum to selectively detect quinone pharmaceuticals by leveraging extracellular electron transfer.

This paper demonstrates a single-cell electrochemical aptasensor array using nanopillar technology and redox-labelled aptamers for detecting EpCAM-expressing cells, enabling early cancer diagnosis.

This study profiles the Mtb transcriptome using SEnd-seq and finds that incomplete transcripts dominate due to low transcription processivity and transcription-translation coupling.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

This paper develops a scalable, GMP-compatible cell therapy for Dystrophic Epidermolysis Bullosa using CRISPR-corrected iPS cells to generate functional skin grafts.

This study shows that Aurora B's spatial separation from outer kinetochore substrates stabilizes biorientation, while its turnover is not essential for this process in budding yeast.

The paper reports structures of Las1-Grc3 complexes and identifies their role in pre-rRNA cleavage during ribosome biosynthesis.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.

This study identifies metabolites and pathways associated with thrombosis after cardiac surgery in children with congenital heart disease using untargeted metabolomics.

This paper reports the first diagnosed case of tenacibaculosis in wild-caught Chinook salmon in British Columbia, Canada, linked to high levels of Tenacibaculum dicentrarchi in skin and gills.

This paper compares the transcriptomes of Plasmodium vivax isolates from different geographical regions, identifying differential gene expression patterns and potential biomarkers for gametocyte detection.

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study shows that cardiac fibroblasts protect cardiomyocytes from ferroptosis and regulate fibrosis after myocardial injury through paracrine factors and Pitx2 signaling.

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

The paper measures how RTX binding to TRPV1 subunits affects channel opening, finding each subunit contributes equally to activation energy.

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

The paper shows that phosphorylation and Lamin B receptor regulate PERIOD protein foci accumulation by modulating the circadian phosphatase MTS and kinase DBT.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study identifies subclonal copy number alterations in relapsed osteosarcoma, showing MYC gain/amplification in treatment-resistant clones and their emergence before chemotherapy.

This paper introduces a new plant transformation method called RAPID that achieves high efficiency and speed without tissue culture.

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

This study identifies Cdc14's role in regulating Rim4-mRNA complex assembly and stability during meiosis through phosphorylation and spatial dynamics.