S. Li

The paper shows autophagy selectively degrades Rim4 during meiosis, sparing bound mRNAs for programmed translation.

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study uses a computational model to show that ventricular systolic function affects thrombus formation after EVAR, with specific correlations identified.

This paper develops a kinetic model for solid waste treatment units using system dynamics and simulation, demonstrating its validity through a 370-day experiment with a prototype.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

This study identifies sRNA candidates in Alcanivorax dieselolei B-5 under alkane and non-alkane conditions, revealing their roles in alkane metabolism and adaptation.

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

This paper develops a therapeutic vaccine using tumor-derived extracellular vesicles modified with polymeric surfactants to enhance immunogenicity and efficacy against melanoma.

This study uses network pharmacology and in vitro experiments to identify Qionggui Power's active ingredients and mechanisms against atherosclerosis, showing suppression of the NF-κB pathway.

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

This study evaluates a method for assessing drug solubility in various milk-related vehicles and finds that milk significantly enhances solubility of poorly water-soluble drugs, though the effect varies by drug.

The paper develops high-performance genetically-encoded green fluorescent biosensors for intracellular L-lactate and demonstrates their utility in live-cell imaging.

This paper identifies mucin 13 as a stress-induced regulator of microbiome shifts and despair behaviors in mice.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The paper identifies MR1-restricted T cell clonotypes associated with resistance to M. tuberculosis infection in a cohort of Ugandan individuals.

This study identifies exodermal suberization as critical for drought tolerance in tomato, contrasting with Arabidopsis endodermis, and highlights the role of MYB92 and ASFT in this process.

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

The paper analyzes Salmonella enterica isolates to show Euramerica's role in global Salmonella spread through pork trade and antimicrobial impact on its evolution.

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

The paper develops a base editor-mediated pipeline in E. coli to screen for functional single nucleotide variants under industrial stress conditions, identifying known and novel mutations.

This study identifies DVG generation in SARS-CoV-2 and links it to IFN stimulation and persistent infection, showing higher DVG levels in symptomatic patients.

This study investigates whether prokaryotic Thoeris TIRs can cross-activate plant TIR-immunity and finds they generate overlapping cADPR isomers but have distinct signaling requirements.

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

This study compares symbiont population differentiation in deep-sea mussels with different ecological niches, finding that habitat homogeneity and mixotrophy reduce geographic structuring of symbiont strains.