X. Li

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study identifies anti-fungal terpenoids from switchgrass ecotypes and shows their differential effects on fungal isolates, supporting their role in microbiome composition.

This paper determines the structure of the talin-KANK1 complex, revealing how KANK1 binds talin and its localization in focal adhesions is regulated by actomyosin tension.

This study identifies the ATM-E6AP-MASTL axis as a timer-like mechanism that ensures the transient DNA damage checkpoint by promoting cell cycle recovery.

This study finds that antibiotic resistance gene co-localization is common in infants' gut microbiomes and linked to immature microbial composition.

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

This study reveals that CD69 acts as a transmembrane protein agonist of S1PR1, promoting Gi-dependent internalization and inhibiting lymphocyte egress.

This study identifies distinct transcriptomic features in satellite cells of extraocular muscles that preserve neuromuscular junctions in ALS mice, suggesting potential therapeutic strategies.

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

This study redirects an exocytic Rab, Sec4, to endocytic vesicles and shows that cells tolerate this misdirection without significant growth defects.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

The paper identifies four WRKY transcription factors upregulated by sugar via a superoxide signaling pathway dependent on hexokinase 1, suggesting a role in plant growth regulation.

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

This study shows that Wg signaling reduces lipid accumulation in Drosophila adipocytes by repressing lipogenesis and fatty acid β-oxidation while promoting lipolysis.

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

This paper identifies PfGCN5 as a key regulator of stress responses in Plasmodium falciparum, showing its role in artemisinin resistance and sensitivity to various stress conditions.

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.

This study shows that EFNB1 levels influence drug response in DLBCL cell lines by affecting phosphorylation networks and sensitivity to targeted and cytotoxic drugs.

The paper establishes a novel MA-K cell line that models primary renal lymphoma and identifies biomarkers predictive of clinical outcomes in DLBCL.

This study shows YAP suppresses AR-driven prostate cancer growth by blocking TEAD-mediated AR signaling through competitive binding.

This study identifies PANK4 as a regulator of lens epithelial fibrosis through its control of PKM2-related glycolysis and EMT.