X. Li

This paper establishes a hairy root culture and genetic transformation system in Stephania tetrandra to enhance bisbenzylisoquinoline alkaloid production.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This study shows that loss of skeletal muscle pyruvate dehydrogenase causes lactic acidosis and early death, but high-fat diets can mitigate these effects.

ProteinGenerator uses a diffusion model based on RoseTTAFold to generate protein sequences and structures simultaneously, validated for functional properties and structural accuracy.

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

This study shows exogenous Complement C3 reduces apoptosis in human cardiomyocytes by interacting with the intrinsic apoptotic pathway.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

The study examines meiotic behavior in tea plant pollen mother cells, identifying normal and abnormal phenomena including cytomixis and other meiotic errors.

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

The paper shows IFN-gamma induces NOS2 and COX2 in ER-breast tumors, linked to poor outcomes, through spatial analysis of tumor microenvironments.

This study shows metformin improves bone healing in diabetic mice by enhancing BMSC differentiation and chondrogenesis.

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

This study identifies curved adhesions as a new type of integrin-mediated adhesion that forms in soft matrices and is crucial for 3D cell migration.

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

This study identifies FAN, a homolog of AATF/Che-1 in Arabidopsis, as essential for genome stability through the ATR-induced DNA damage response pathway.

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

This study identifies a conserved MAPK cascade in S. sclerotiorum essential for growth, development, and virulence, and demonstrates its targeting by HIGS reduces pathogen virulence.

This study uses bulk RNA-sequencing to compare gene expression in small airway cells from IPF and post-COVID fibrosis patients, revealing disease-specific genetic signatures and differential responses to TGF-β1 treatment.