X. Wang

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

The paper investigates how compensation between paralogs evolves in plant stem cell control, showing that a single amino acid change and cis-regulatory variation can reduce compensatory ability in tomato.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

The paper derives an analytical solution for root pressure and applies it to a 7-meter bamboo shoot's hydraulic architecture.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

This study examines the relationship between optic nerve head strains under IOP elevation and retinal sensitivity in glaucoma patients, finding stronger associations in high-tension glaucoma compared to normal-tension glaucoma.

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

The paper identifies a conserved amphipathic helix in viral replication proteins that directs their membrane association and VRC localization across different viruses.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

The paper characterizes epigenetic alterations in esophageal cancer using whole-genome bisulfite sequencing and identifies novel clusters and molecular features in two subtypes.

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

This study identifies and classifies 25,498 gamma-type Env-containing ERVs in anamniotes, revealing genetic diversity and evolutionary patterns through phylogenomic analysis.

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

The paper uses molecular dynamics simulations to analyze how three imidazoquinoline agonists selectively bind to TLR7 and TLR8, revealing van der Waals interactions as key to their selectivity.

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

This study shows that inhibiting Tip60 acetyltransferase with TH1834 improves cardiac function and reduces damage after myocardial infarction in mice.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.