Y. Chen

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.

This study shows that TM6SF2 overexpression or loss-of-function alters lipid metabolism in human liver cells by changing lipid species composition and gene expression.

This study shows elevated temperatures enhance vascular regeneration in plant grafts, mediated by leaf-derived auxin, and this effect is not limited to graft healing.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

This paper presents a drug candidate, NANA-Me, that prevents and treats ADAA-based diseases caused by pathogenic anti-spike antibodies in COVID-19 and vaccines.

This study investigates how nanobody binding stabilizes the active state of the β2-adrenergic receptor and modulates ligand affinity through conformational changes and allosteric signaling.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

This study analyzes rhizosphere bacterial diversity of Angelica dahurica var. formosana across different sites and varieties, finding stable communities and key taxa linked to yield and quality.

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

This study identifies genetic mutations in Zymomonas mobilis that cause self-flocculation by disrupting gene function and increasing c-di-GMP levels, enabling improved biomass recovery and productivity.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This study generates human chambered cardiac organoids from pluripotent stem cells to model cardiac hypertrophy and improve cardiovascular disease research.

This study investigates how the lateral size of graphene oxide affects its uptake mechanisms and intracellular fate in mammalian cells over time.