Y. Zhang

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

The paper develops a diversified library of nucleoside analogues with enhanced antiviral efficacy and low cytotoxicity, featuring a novel carbobicyclic core structure.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

This study identifies NOP16 as a histone mimic that regulates H3K27 methylation and gene repression, showing its role in breast cancer progression.

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

The paper investigates how linker length affects phase separation in the Rubisco-EPYC1 system of green algae, finding that shorter linkers significantly reduce critical concentrations.

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

AutoUnmix is a deep learning-based spectral unmixing method for multi-color fluorescence microscopy that outperforms existing methods in speed and accuracy.

This paper develops a potent MAPK13-14 inhibitor, NuP-3, which reduces airway inflammation and mucus production in human airway models and minipig disease models.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

The paper develops a method to recover full-length BCR sequences from single-cell RNA libraries and applies it to study convergent B cell responses to vaccination in rhesus macaques.

This study shows IL-1β promotes MPN initiation by enhancing early clonal expansion of JAK2-mutant HSCs in a mouse model.

The paper uses multiscale imaging to study corneal endothelium damage in mouse models, finding that Rho Kinase inhibitors reduce fully-distorted tight junctions under acute ocular hypertension.

The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.

The paper tests a palmitoylated HR2-derived peptide's ability to inhibit SARS-CoV-2 pseudoviral fusion and finds it reduces fusion activity by 76% at 10 M.

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

This paper reviews Australian literature on nature-based solutions, finding inconsistent definitions, urban focus, and lack of policy integration, and recommends standardization and collaboration.

This paper introduces a quantitative method to analyze mitochondrial morphology using 3D single-molecule localization microscopy, validated with simulated data and tested on altered mitochondria.

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

This paper develops a co-culture platform to create photosynthetic living fibers using algal-bacterial consortia with controlled spatial distribution for bioremediation and advanced materials.

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.