Y. Zhang

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

This paper introduces a Bayesian topic model to analyze single-cell RNA-seq data and identifies dynamic gene programs in pancreatic cancer associated with prognosis and immune pathways.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This study reports cryo-EM structures of zebrafish P2X4 receptors bound to antagonists, revealing ligand-dependent structural changes that explain subtype-specific allosteric inhibition.

The paper shows that intrinsically disordered regions (IDRs) in biomolecular condensates exclude intruders via conformational entropy, with exclusion efficiency increasing with IDR concentration and intruder size.

This study shows that GM130 and RNA form condensates that scaffold the Golgi ribbon, and disrupting this interaction disrupts ribbon structure.

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study investigates the role of the NDH complex in maize by analyzing mutants, finding it regulates carbon flow and redox balance in C4 photosynthesis.

This study identifies TRMT1 as a target of SARS-CoV-2 Mpro, showing cleavage disrupts its tRNA methyltransferase activity and impacts host translation and oxidative stress response.

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

The paper critiques the maximum genetic diversity hypothesis and its application to modern human origins, highlighting serious issues with the model.

This study analyzes RBC metabolism in 587 SCD patients to compare Hb SS, SC, and transfused AA RBCs, finding genotype-specific metabolic changes linked to hemolysis and organ dysfunction.

This study reprograms human fibroblasts into anti-aging neural stem cells using miR-302a, which enhance cognitive function and extend lifespan in mice with Alzheimer's.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

This study evaluates Wolbachia strains in Saudi Arabian mosquitoes for dengue suppression in extreme environments, finding reduced heat tolerance and local adaptation effects.

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

This study identifies a common mechanism by which bacterial biofilms resist antibiotics through lipid metabolism activation that reduces drug penetration and increases glucose consumption.

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

This study reports the first complete mitochondrial genome of Strix aluco, identifies its divergence time, and links geographic and climatic factors to its speciation.