Y. Zhang

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

This study shows AmotL2 regulates YAP promoter accessibility through chromatin remodeling in endothelial cells under mechanical stress.

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

The paper develops a label-free optical imaging method for the lymphatic system using deep learning and applies it to clinical and animal studies.

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

The paper compares metagenomic and metatranscriptomic data with biogeochemical model predictions to identify discrepancies in microbial gene abundance and function in the Chesapeake Bay.

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

This study identifies T cell epitopes and cross-reactivity patterns across common cold coronaviruses, highlighting conservation and limitations in cross-reactivity among subgenera.

This paper introduces MUSI, a rapid, label-free imaging method for lung adenocarcinomas, showing it can differentiate subtypes with resolution comparable to FFPE histology.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

This paper designs and characterizes lipid nanocarriers for oral delivery of immunotherapeutic peptides, showing they are non-toxic, taken up by immune cells, and accumulate in lymph nodes.

This study shows engineered graphene quantum dots inhibit and disassemble tau protein aggregates in vitro, suggesting their potential as a treatment for tauopathies.

This study examines TE load variation in Arabidopsis during range expansion, finding increased TE load with expansion and identifying effective population size and transposition rates as key factors.

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.

This paper introduces new mouse models expressing human HIV-1 broadly neutralizing antibody (bnAb) precursors with more physiological levels and diversity, enhancing vaccine research for bnAb elicitation.

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

This paper investigates the role of MoCK2 in rice blast fungus metabolism and mitochondrial protein import, finding it affects acetyl-CoA production and mitochondrial function essential for pathogenesis.

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

This study identifies disruption of the nuclear localization signal in RBM20 as a causative mechanism in dilated cardiomyopathy through impaired nucleocytoplasmic transport.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

The paper examines the relationship between ecological traits and olfactory receptor gene expansions in ray-finned fishes, finding convergent increases in olfactory system size in amphibious species.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study shows that AcrVA2 inhibits Cas12a mRNA translation, reducing its anti-phage activity and enabling specific inhibition of Cas12a orthologs.

This paper compiles a large dataset on root structural traits and confirms a universal allometric relationship across plant species and environmental conditions.