Z. Jiang

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study identifies SNHG1 as a regulator of LPS-induced acute lung injury by modulating the miR-421/TIMP3 axis in A549 cells.

This study identifies TRPM7's role in synaptic vesicle endocytosis and short-term synaptic depression in neurons.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This study shows that the hydrophobin HYD3 from the specialist fungal pathogen Metarhizium acridum activates immunity in its host locust but not in non-host insects.

This study shows that certain aminoglycoside antibiotics inhibit mycobacteriophage infection while others do not, suggesting a mechanism involving the amino sugar group.

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

This study develops miR-145-loaded nanoparticles to target VSMC phenotype switching and atherosclerosis, showing reduced plaque growth and restored contractile markers in vitro and in mice.

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

This study investigates the catalytic properties of the mitochondrial rhomboid protease PARL using in vitro assays, revealing substrate preferences and activity enhancements under specific conditions.

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.

This study shows that pattern-recognition receptors (PRRs) are essential for NLR-mediated immunity in plants, revealing a unified model where PTI supports ETI during bacterial infection.

This study uses simulations to show how transcription affects nucleosome positioning differently in yeast and mouse, revealing enzyme competition and polymerase effects.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

This study shows that Survivin depletion in cells leads to evasion of Docetaxel-induced mitotic block and apoptosis, increasing mitotic catastrophe and senescence, thereby enhancing drug efficacy.

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The paper develops a theoretical framework to model nucleosome positioning by approximating ATP-driven remodeling enzymes with effective equilibrium models, validated through simulations.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This study finds that TP53 mutations in breast cancer increase immunogenic activity, suggesting they could be a biomarker for immunotherapy response.