Z. Li

This paper demonstrates that the hypercompact Cas{Phi} nuclease can generate heritable gene edits in Arabidopsis with high specificity and efficiency, and shows that its performance is influenced by chromatin environment and temperature.

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

This study identifies the N-terminal extension of Arabidopsis AGO1 as essential for miRNA activity, showing its role in miRNA loading and trans-acting siRNA biogenesis.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

The paper shows that aberrant cell state plasticity, driven by regenerative activity and developmental reprogramming, occurs before colorectal cancer initiation in mouse models and human patients.

This study shows that microtubule disruption impairs GLUT4 trafficking in skeletal muscle, contributing to insulin resistance.

The paper shows that siderophore-mediated iron partition enables stable coexistence between cheaters and partial cooperators in microbial communities.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This paper designs optimized monophasic TMS pulses that reduce coil heating while maintaining neuromodulation effectiveness, enabling higher pulse rates.

This study shows that peptide sequences from ostrich eggshells survived for 6.5-9 million years, extending the known preservation of ancient proteins to the Miocene.

This study shows that the Drosophila Toll pathway and specific Bomanins enhance resilience to Aspergillus mycotoxins by mitigating toxin effects rather than directly killing pathogens.

This study identifies heterocateny as a structural variation caused by HPV integration, promoting intratumoral heterogeneity and clonal evolution in oropharyngeal cancers.

The paper identifies a long non-coding RNA that regulates IRF8 autoactivation through a negative feedback loop in dendritic cell differentiation.

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

This study identifies PDLP5 and PDLP6 as proteins regulating plasmodesmal function at specific cell interfaces in Arabidopsis by interacting with SUS6 and CalS7 to control callose deposition.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.