Z. Li

This study demonstrates that selective PIN1 inhibition in CAFs and engagement of T lymphocytes using a bispecific system effectively eradicates pancreatic tumors in mice.

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

The paper identifies BNIP5 and Bcl-G as anti-apoptotic BH3-only proteins that inhibit Bak activation, preventing apoptosis.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

The paper identifies how MBNL proteins localize RNAs via kinesin interaction and membrane docking, using a modular approach to study RNA-binding protein functions.

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study identifies resting-state network hubs involved in memory consolidation through chemogenetic suppression, showing their causal role beyond the hippocampus.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

The paper reanalyzes ancient whole-genome duplication events in leptosporangiate ferns using phylogenetic methods and substitution rate corrections, identifying four WGDs and highlighting methodological uncertainties.

This study evaluates whether a unified model can predict plant and leaf parameters of winter wheat using vegetation indices across growing seasons, finding that hierarchical linear models (HLM) are stable and applicable across seasons for most parameters.

The paper uses gene expression and metabolic flux analysis to show that metabolic scaling occurs in multiple pathways across species, not just oxygen consumption.

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.