C. Ma

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

This study identifies tropifexor as a potent SARS-CoV-2 PLpro inhibitor through drug repurposing screening, showing antiviral activity in Calu-3 cells.

The paper validates or invalidates reported SARS-CoV-2 PLpro inhibitors using enzymatic, thermal shift, and cell-based assays, finding most compounds lack binding or cellular inhibition.

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

The paper identifies TGF-β-dependent differentiation of stem-like CD8+ T cells into tissue-resident memory T cells in tumor draining lymph nodes, which negatively correlates with tumor vaccine response.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

The paper designs and evaluates Vitamin E analogs with targeting and cleavable features to reduce Doxorubicin cardiotoxicity in cancer treatment.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

The paper validates a 48-gene NGS panel for detecting actionable genomic mutations in myeloid neoplasms, showing high sensitivity and specificity.

This paper isolates and characterizes a quinclorac-degrading bacterium, Cellulosimicrobium cellulans sp., showing 45.9% degradation efficiency and identifying two novel degradation products.

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

The paper introduces site-specific phosphorylations in PSD-95 and shows how they affect phase separation with interaction partners, revealing opposing effects on condensate formation.

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

This study investigates TAK1's role in retinal neovascularization and shows that inhibiting TAK1 reduces aberrant angiogenesis in a rat model.

Under constant infection by Sclerotinia sclerotiorum, BnaA03.WRKY28 interacts with BnaA09.VQ12 and takes precedence over phosphorylated BnWRKY33 to bind to the BnWRKY33 promoter, thereby weakening resistance but promoting branching.

This study examines how breast cancer tumors evolve during early stage treatment with combination CDK and endocrine inhibitors, finding convergent resistance pathways and increased subclonal diversity with combination therapy.

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

The paper introduces iwa-miRNA, a web-based tool for interactive annotation of plant miRNAs using sRNA-Seq data and manual curation.

This study identifies four compounds with broad-spectrum antiviral activity against multiple coronaviruses, including SARS-CoV-2, by inhibiting viral Mpro and cathepsin L.

This study shows that six compounds inhibit SARS-CoV-2 Mpro non-specifically and their antiviral activity cannot be predicted by IC50 values in the absence of DTT.

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

This study identifies ARL15 as a regulator of magnesium homeostasis by promoting N-glycosylation of CNNM proteins, which affects Mg2+ uptake in kidney cancer cells.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.