C. Wang

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

This meta-analysis compares the consistency of superb microvascular imaging and contrast-enhanced ultrasonography in detecting intraplaque neovascularization, finding a high Kappa index indicating good agreement.

This paper reports a human monoclonal antibody that neutralizes SARS-CoV-2 and SARS-CoV, targeting a shared epitope for potential prevention and treatment of COVID-19.

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

The paper investigates how CpG site number and DNA methylation vary across a Kenyan house sparrow range expansion, finding increased CpG sites at the invasion front and altered methylation patterns linked to phenotypic plasticity.

The paper identifies 56 beneficial genes for optimizing free fatty acids production in E. coli using CRISPRi-Omics and reports a record FFAs titer of 21.6 g L-1.

This paper introduces sapphire-supported nanopore membranes with reduced capacitance and noise, improving DNA sensing accuracy and speed compared to silicon-supported nanopores.

This study analyzes plant responses to water stress through a global meta-analysis, finding that ROS overproduction is a primary response mechanism and that plants acclimate over time.

This study uses HETEROID to analyze how FAK, Rac, Rho, and Cdc42 inhibitors affect VSMC spheroid formation and morphology, revealing pathway-specific responses.

This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.

The paper identifies the polyamine pathway as a regulator of Th17/Treg balance, showing its impact on inflammation and T cell phenotype.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

The paper introduces a deep learning method to predict virus hosts using DNA sequences, applied to 2019-nCoV to identify potential hosts like bats and minks.

This study uses ribbon-scanning confocal microscopy to compare the outflow tract anatomy of human and porcine eyes, finding humans have fewer and larger collector channels.

This study examines how different doses of netarsudil affect intraocular pressure and vessel diameter in porcine anterior segments with and without trabecular meshwork removal.

This study identifies therapy-induced lipid uptake and remodeling as drivers of ferroptosis hypersensitivity in prostate cancer, offering new strategies to combat drug resistance.

This study develops a rabbit-derived anti-TNFα monoclonal antibody (HZ3M) showing improved neutralizing activity and longer half-life compared to existing therapies like Humira.

The paper shows that boron deficiency reduces brassinolide accumulation by downregulating BR6ox1 and BR6ox2, thereby inhibiting root growth through BR signaling.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

This study shows that deoxynivalenol (DON) promotes PEDV infection and worsens gut barrier injury by inducing autophagy and impairing innate immunity.

This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.

This study investigates how CXCL12 affects human sperm motility and chemotaxis through its receptors CXCR4 and CXCR7, finding CXCR4 is the dominant mediator.

This study shows TGF-β signaling is essential for maintaining tendon cell identity, as its disruption leads to dedifferentiation and loss of markers in tenocytes.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

This study shows that flagellin methylation in Salmonella enhances adhesion and invasion by increasing surface hydrophobicity, aiding gut colonization and host infection.

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.