D. Wang

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.

This study shows that S1PR1 and S1PR3 regulate SR-B1 expression in human aortic endothelial cells through transcriptional and post-translational mechanisms.

This study identifies allosteric HSP70 inhibitors that overcome proteasome inhibitor resistance in multiple myeloma by targeting mitochondrial HSPA9 and disrupting mitoribosome stability.

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

This study identifies Nck1's role in flow-induced endothelial activation and atherosclerosis by showing its necessity for IRAK-1 activation and inflammation.

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This paper develops a machine learning method using entropy features from high-frequency iEEG subbands to accurately identify epileptic focus in patients.

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

The paper constructs an adult human cell atlas from 84,363 cells across 15 organs, identifying 252 cell subtypes and revealing inter- and intra-organ heterogeneity.

This study investigates DNA methylation variation during maize domestication using WGS and WGBS, identifying DMRs linked to gene regulation and adaptation.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that CAPG, a conserved protein, induces transcriptional changes in endometrial cells of humans and cattle, potentially aiding implantation across species with different implantation strategies.

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

This study shows that integrin affinity modulation is critical for endothelial activation in response to atheroprone hemodynamics and oxidized lipoproteins, with talin1 L325R mutations impairing this process.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

The paper measures protein turnover rates in collagen and glycoprotein phases of rat Achilles tendon using isotope labeling and mass spectrometry, finding significant differences in proteome dynamics between the two ECM phases.

This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

The paper investigates causes of infertility and embryo mortality in captive zebra finches, finding inbreeding, age-related decline, and poor nutrition significantly impact reproductive success, but explain only a small portion of the variance.

This study examines how zinc and calcium ions affect the structure and mechanics of vimentin intermediate filaments, showing that zinc is more effective at lower concentrations and that ion binding can compete.

This paper uses a mathematical model to analyze CAR T-cell killing dynamics in glioma, showing dose-dependent effects on proliferation and exhaustion.