D. Wang

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

The paper examines how different force fields affect protein refolding pathways using a mechanically perturbed titin domain model and a helical peptide, finding significant differences in refolding ability and helical lifetimes.

The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.

This study identifies TNK2, WASL, and NCK1 as host factors critical for multiple picornavirus infections, showing they function in a common pathway during viral entry.

This study identifies TAG-63 as a neurofilament-like protein in C. elegans and shows its role in axonal transport by interacting with UNC-104 and affecting motor speed and filament stability.

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

This paper shows that drh-1 in C. elegans mediates the Intracellular Pathogen Response (IPR) to viral infection, acting as a pattern-recognition receptor independent of its role in RNAi.

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

This study identifies stable reference genes for RT-qPCR normalization in Hypericum perforatum across tissues, developmental stages, and stress conditions.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.

The paper finds that conservative amino acid changes are more common in fixed and standing missense variations of slow evolving proteins, suggesting these variations are more neutral and suitable for phylogenetic inferences.

The paper shows CDK1 phosphorylates ULK1-ATG13 in mitosis to regulate autophagy and Taxol sensitivity, with implications for cancer therapy.

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

The paper identifies a new RNA virus infecting Caenorhabditis nematodes, describes co-infections and reassortment patterns, and shows host-virus genotype interactions affecting competition.

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

This study examines how Plasmodiophora brassicae infection alters the fungal endophyte community in stem mustard roots using sequencing and culture methods, finding reduced diversity and shifts in dominant taxa.

This study uses oligotyping and genome-resolved metagenomics to identify distinct Candidatus Accumulibacter communities in different EBPR configurations, revealing new MAGs and clade-level diversity.

The study tests the intersexual pleiotropy hypothesis by examining genetic and environmental influences on female extra-pair mating in zebra finches, finding no genetic homology between male and female promiscuity.

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.

This paper demonstrates a gene therapy approach using NF-κB-activated CRISPR/Cas9 to specifically target and kill cancer cells without affecting normal cells.

The paper uses single-cell RNA sequencing to analyze antler stem cells, finding they form a homogeneous population with unique gene expression patterns and potential as a model for regeneration.

This study develops a CRISPR-assistant trans enhancer to efficiently activate gene expression by combining dCas9-VP64/sgRNA with a CMV enhancer.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.