G. Chen

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

The paper identifies increased α-ketoglutarate (AKG) as a key factor in the transition from C3 to C4 photosynthesis in Flaveria species, supported by metabolomic, sequence, and simulation analyses.

This paper develops a mathematical model to predict SARS-CoV-2 neutralizing antibody levels post-vaccination and assess their relationship to protective immunity.

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

This study evaluates how reduced nitrogen and water supply affects deep nitrogen and water uptake in winter oilseed rape, finding that nitrogen supply primarily influences deep nitrogen uptake efficiency.

The paper identifies a gene cluster involved in anaerobic dichloromethane degradation and shows its widespread distribution in diverse environments, suggesting significant DCM attenuation and potential bioremediation applications.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This paper develops bioluminescent synthetic cells that communicate with natural cells and self-activate light-responsive proteins, enabling in vivo applications without external light sources.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

This study identifies VENTHEART as a lncRNA essential for cardiomyocyte specification, maturation, and function, with potential relevance to heart disease.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

This paper investigates how TxtC catalyzes sequential hydroxylation of thaxtomin D, revealing that aliphatic hydroxylation is preferred due to lower energy barriers and conformational changes induced by intermediate hydroxyl groups.