H. Chen

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

The paper shows that phyB induces alternative splicing of PIF3, leading to intron retention in the 5UTR and uORF-mediated translational inhibition, regulated by the short-day diurnal cycle.

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

This study shows CpG-ODN 2007 reduces mortality and toxicity in zebrafish infected with Vibrio vulnificus and modulates immune gene expression.

This study uses scRNA-seq to analyze aging effects on mammary gland cell populations in mice, identifying age-related gene expression changes and a decline in a specific luminal cell subset.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study shows that the OR1D2 receptor mediates bourgeonal-induced CatSper activation through a G-protein-cAMP pathway in human sperm.

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

The paper develops an integrated multi-omic framework to study the plant response to jasmonic acid, identifying new regulatory components and crosstalk points with other signaling pathways.

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

The paper identifies a direct mechanical signal transfer pathway between β1 integrin, CD98hc, and TRPV4 channels that mediates ultra-rapid transmembrane mechanochemical conversion in focal adhesions.

rhizoTrak provides a user-friendly Fiji plugin for efficient manual annotation of time-series minirhizotron images, offering flexibility and automation for root structure analysis.

The paper examines how one-time nitrogen fertilization affects soil microbiomes in switchgrass fields, finding that spatial and temporal variation outweighs fertilization effects.

The paper detects Leishmania spp. in snakes from Northwest China and identifies three species using phylogenetic analysis.

This study shows KGF induces podosome formation in HIOECs through integrin-Erk1/2 signaling, enhancing epithelial adhesion and rete peg elongation.

This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.

This study identifies AhRLK1, a peanut receptor-like kinase, which enhances resistance to Ralstonia solanacearum in tobacco through hypersensitive response and hormone signaling.

This study shows that extracellular cations alter nuclear shape and mechanics through heterochromatin formation, rescuing nuclear morphology in disease models.

This study identifies lysosomal function as a regulator of cellular quiescence depth, showing it acts like a dimmer switch to modulate quiescence and link it to senescence and aging.

This study characterizes the structural complexity and epigenomic impact of T-DNA insertions in Arabidopsis using long-read sequencing technologies.

This study compares the microbiome of Schlechtendalia chinensis aphids on two host plants, finding distinct bacterial communities associated with each host.

This study shows that pyruvate carboxylase (PC) is critical for pulmonary metastasis of breast cancer, as its depletion reduces lung metastasis without affecting primary tumor growth.

This study evaluates a novel antibiotic-free gas plasma-activated catheter lock solution, showing it effectively eradicates biofilm microbes and is less toxic to human cells than a standard solution.

This study uses CRISPR-Cas9 to efficiently edit the Magnetospirillum magneticum AMB-1 genome, revealing Amb0994's role in magnetotactic behavior through flagellar control.

The paper identifies social behavior and anxiety as key predictors of nicotine self-administration in adolescent rats, with significant sex differences observed.

The paper develops a sensitive fluorescence assay to identify dynamin GTPase inhibitors and finds that existing compounds like Dynasore and Dyngo-4a do not inhibit basal activity.

This study applies Mondrian cross-conformal prediction to estimate prediction confidence on large imbalanced bioactivity datasets, showing improved performance for minority classes.