J. Chen

This study examines how climate and competition influence elevational distributions of tropical Drosophila species in the Australian Wet Tropics, finding that thermal tolerance and interspecific competition drive community composition at different elevations.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

This study shows that PPAR-γ activation with rosiglitazone reduces oxidative stress and promotes xenograft regeneration in a dental follicle cell model.

This paper develops a bifunctional reaction system to simultaneously resolve lipid positional and geometric isomers using mass spectrometry, revealing structural patterns in bacteria and tracking changes in mouse brain ischemia.

This paper develops two CRISPR-based systems for genetic manipulation in Acidithiobacillus ferridurans, achieving efficient gene knockdown and genome editing with significant effects on sulfur and iron metabolism.

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.

This study uses molecular dynamics simulations to show that ShHTL7 and AtD14 adopt active conformations without ligand, but ShHTL7 has a higher population in the inactive state due to sequence differences affecting binding pocket closure.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

This paper designs and synthesizes SPIO-HGNS nanoparticles with tunable SPR in the NIR range to enhance photothermal conversion for potential photothermal therapies.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study shows that PDX models of pediatric AML retain patient-like gene expression patterns and identify therapeutic targets.

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

This study identifies the molecular basis of fidaxomicin's narrow-spectrum activity against Clostridioides difficile by analyzing its interaction with RNA polymerase.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

The paper uses genomic data to show that natural selection and demographic history jointly shaped the genetic structure and contact zones in Norway spruce during post-glacial recolonization.

This study compares cellular diversity between Xenopus pronephric and mouse metanephric nephrons using single-cell RNA sequencing to identify conserved and divergent cell types and expression profiles.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study examines if SARS-CoV-2 infection during pregnancy leads to lasting changes in maternal cytokine levels, finding no significant differences between infected and uninfected groups.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

This study assesses the infectivity and immune evasion of the Omicron SARS-CoV-2 variant using pseudotyped viruses and neutralizing assays against convalescent sera and vaccinated individuals.

This paper develops a PBPK model to predict the biodistribution of magnetic nanoparticles under SMF and shows improved brain bioavailability with SMF and insulin conjugation.

This study shows E. coli kills S. aureus via colibactin and identifies BarA-UvrY as a novel regulator of the pks island involved in this process.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

The paper describes how enteroblasts in Drosophila midgut form an apical domain by creating an apical membrane initiation site and integrating into the epithelium.

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.