J. Yang

The paper identifies divergent iron-regulatory states in triple-negative breast cancer cells that correlate with invasive and non-invasive phenotypes and predict patient outcomes.

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

This study compares classic and revised anxiety-like assays in mice, finding that assay choice depends on grouping variables and that revised assays may offer better ecological validity.

This study shows that partially hydrolyzed guar gum improves survival and reduces weight loss in SARS-CoV-2 infected Syrian hamsters by modulating gut microbiota and metabolites.

This study shows that IL-27 induces HIV-resistant dendritic cells that suppress reverse transcription post-virus entry, independent of SPTBN1, autophagy, and YB-1.

This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.

This study examines OCT1 mutations to understand their impact on drug response and identifies population-specific allele frequencies linked to LDL cholesterol levels.

This study identifies apicoplast transporters in Toxoplasma gondii using TurboID and genome engineering, showing AMT1 and AMT2 are critical for parasite growth and virulence.

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

This study shows that TRAIL+ cancer cells use noncanonical TRAIL signaling in MDSCs to promote their abundance and tumor progression in cholangiocarcinoma.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

DeCOIL optimizes degenerate codon libraries for ML-assisted protein engineering to generate diverse and high-fitness protein variants.

This study investigates reciprocal interactions between human subpallial telencephalic organoids and GBM spheroids, identifying transcriptional changes linked to neuronal differentiation, angiogenesis, and tumor plasticity.

This study investigates the functional roles of CSLD2, CSLD3, and CSLD5 proteins in cell wall synthesis in Arabidopsis, showing their conserved {beta}-1,4 glucan synthase activities and distinct contributions to cell plate formation.

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

This paper develops SLR-LNPs, a nanoparticle-based RIG-I agonist, showing enhanced tumor immunogenicity and improved response to immune checkpoint inhibitors in mouse cancer models.

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

The paper shows that quorum sensing in Staphylococcus aureus controls phage susceptibility by modulating receptor structures, and that cross-species communication with non-aureus staphylococci can protect S. aureus from phage infection.

This study identifies aged breast matrix-bound vesicles (MBVs) that promote cancer invasiveness by altering miRNA and cytokine profiles in human mammary epithelial cells.

This study shows that mitochondrial GTP metabolism regulates reproductive aging in C. elegans by controlling mitochondrial dynamics and homeostasis.

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.