J. Zhang

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

The paper demonstrates mating between haploid cells with human GPCRs and enables hGPCR signaling in probiotic yeast using transcriptome analysis and ligand-free screening.

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

This study examines nitrate-dependent Fe(II) and As(III) oxidation by Acidovorax sp. strain ST3, identifying Fe(III) minerals and their As immobilization capabilities.

The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study analyzes the impact of socio-economic factors on surface water quality at provincial boundaries in China, identifying key factors affecting water quality.

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.

This study shows that human intestinal epithelial cells use caspase-1/4-dependent inflammasomes, not NAIP/NLRC4 or NLRP3/ASC, to respond to Salmonella Typhimurium.

This study identifies CFAP61 as essential for sperm flagellum formation and male fertility in humans and mice, showing its role in axoneme stabilization and its mutation causing infertility.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study shows that traumatic brain injury (TBI) rapidly induces splenic dendritic cell maturation via FLT3/FLT3L signaling, which is enhanced by ethanol intoxication.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

BCM3D 2.0 improves 3D bacterial cell segmentation in dense biofilms by using intermediate image representations generated by CNNs, enhancing accuracy even at low signal-to-background ratios.

The paper uses multimodal imaging and single nuclei RNA-sequencing to study how type I interferon affects viral tropism in the brain during flavivirus infection in mice.

This study reveals how PLN mutations reduce phosphorylation by altering conformation and PKA interactions, contributing to DCM.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies genetic and epigenetic variations associated with the rapid radiation of Aquilegia species by analyzing genomes and methylomes across three lineages.

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

The paper analyzes nsSNPs in the CCM2 PTB domain to assess their structural impact, finding that pathogenic variants affect only one of the dual cores, supporting their independent functionality.

This study shows that the PHR2 gene regulates arbuscular mycorrhiza symbiosis by controlling phosphate starvation responses in rice, enhancing root colonization and phosphate uptake.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

The paper identifies GbNGT1, an N-glucosyltransferase that catalyzes IAA and IAA-amino acid glucosylation, completing the auxin metabolic pathway.

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

Cross-species network analysis identifies and validates new growth regulators in Arabidopsis by integrating transcriptional networks and functional orthologs.