J. Zhao

This study identifies a two-step cysteine modification mechanism and a conserved calcium binding pocket in TRPA1 that govern its activation and calcium modulation.

This paper introduces an FNC-based GAN for classifying mental disorders from fMRI data, achieving higher accuracy than existing methods in MDD and schizophrenia classification.

The paper constructs an AI-RIL population and generates a de novo genome assembly for B. rapa to study natural variation and improve genetic mapping resolution.

The paper localizes Fusarium hyphal growth in FHB-infected grains during malting and links it to mycotoxin production using microscopy and metagenomics.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study investigates the ATPase activity of BfpD, a type IV pilus extension ATPase in EPEC, revealing contamination issues and functional differences between BfpD and BfpF mutants.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

This study shows that skin scarification delivery of MVA vectors generates robust T cell immunity against respiratory viral challenges, outperforming other routes and suggesting its potential for vaccines like COVID-19.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

The paper optimizes the RNAscope RNA-ISH method for plant tissues, enabling spatial gene expression visualization in barley and Arabidopsis.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

This paper demonstrates the feasibility of using microelectrophoresis to deliver nanoparticles into living cells, showing successful ejection of quantum dots into human kidney cells with minimal damage.

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.

The paper develops CM93, a novel EGFR inhibitor with improved targeting and brain penetration, showing better efficacy and safety in mouse models of EGFR-mutant NSCLC and brain metastases.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

The paper identifies RNA G-quadruplex structures in Arabidopsis and rice, showing they regulate translation and plant growth.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.

This study shows GLUL promotes lung cancer cell growth under glutamine sufficiency through enzyme-independent upregulation of CaMK2G.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.