L. Chen

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

This paper describes a low-cost, benchtop method for fabricating carbon fiber microelectrode arrays with improved tip optimization techniques.

This study examines how two populations of estuarine cordgrass show opposite DNA methylation patterns under heat stress, suggesting epigenetic mechanisms may enable rapid adaptation to urban environmental challenges.

The paper identifies bacterial structural variants associated with bile acid metabolism in humans using metagenomic data from two Dutch cohorts.

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

The paper develops an RNA editing signature (GCRE) to predict chemotherapy response in gastric cancer, achieving 84% accuracy and showing better outcomes in patients with higher editing levels.

This study identifies sexual dimorphism in NMIBC immune microenvironment, showing higher CD163+ macrophages and PD-L1 in female tumors, linked to worse recurrence-free survival.

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

The paper develops a fluorescence-based assay for NatD to identify small-molecule inhibitors, finding two hits from a compound screen.

This study investigates SIM artifacts caused by light scattering in thick samples and shows how sample thickness affects 2D-SIM image reconstruction.

This study identifies that increased ketohexokinase-A promotes fructose-induced podocyte hypertrophy through activation of IL-6/STAT3 signaling.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

This study shows Mer2 phase separation forms droplet-loop chromatin structures to enable diverse meiotic DSB formation.

This study examines how temperature affects the life history traits of Trichogramma achaeae, showing that acclimation influences fecundity, development time, and wing size but not longevity.

The paper evaluates drug-drug interactions in triple artemisinin-based combination therapies (TACTs) using an in vitro high-throughput process to identify genotype-dependent susceptibility and antagonism.

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study identifies environmental and lifestyle factors shaping the gut microbiome in a large Dutch cohort, finding that most microbiome variation is due to environment rather than genetics.

This study investigates how environmental factors like light, temperature, depth, drought, and salt stress affect white clover seed germination and emergence, finding optimal conditions for successful establishment.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

This paper proposes a nondestructive method using biophotons to detect wheat mould, achieving 93.6% recognition accuracy via SVM classification of approximate entropy features.