L. Yang

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This paper introduces a cell tracking method for label-free phase contrast imaging in microfluidic devices, improving tracking accuracy by incorporating velocity fields and modifying DeepSORT.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

The paper develops trophoblast organoids with physiological polarity to model placental structure and function, showing improved hormone secretion and syncytium size.

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

The paper identifies a shared ubiquitin-proteasome pathway for degrading TOC and TOM tail-anchored receptors in Arabidopsis thaliana.

The paper sequences and assembles the nuclear and mitochondrial genomes of Bipolaris sorokiniana strain LK93 to improve understanding of its interaction with wheat.

This study identifies SPL genes, particularly SPL10, as activators of age-related resistance in Arabidopsis during vegetative phase change by enhancing the salicylic acid pathway.

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

The paper develops a computational model to study antibody evolution after vaccination with designed influenza immunogens, finding that a chimeric antigen outperforms a cocktail in eliciting RBS-directed antibodies due to T cell interactions.

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

The paper shows that antigen presentation dynamics after multiple vaccinations influence the immune response to SARS-CoV-2 Omicron by shaping B cell responses and antibody targeting of epitopes.

This study identifies HCN ion channels as evolutionarily conserved pacemakers in smooth muscle, showing their role in peristalsis and pacemaker activity in the urinary tract.

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

This study analyzes genomic diversity in Asian white birch to identify signals of adaptation and hybridization, finding 7,609 SNPs associated with environmental variables and highlighting climate change risks.

This study investigates how L-norepinephrine affects wastewater microbiomes, showing it induces community shifts, oxidative stress, metabolic changes, and increased virulence potential.

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

This paper proposes strategies to extract fibril structure and tissue organization information from SAXS data of fibrils in tissue thin sections, leveraging micro- and nano-beam x-ray scattering.

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

The paper shows that Arabidopsis HSC70.1 binds its own mRNA to inhibit translation, forming a feedback loop that regulates chaperone availability and enables non-cell-autonomous homeostasis.