M. Wang

This study shows that blood collection tubes affect biomarker screening results in mass spectrometry, with coagulant tubes altering protein profiles and reducing biomarker detection.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

The paper examines the expression of SARS-CoV-2-related molecules in human tissues and immune cells across health and disease states, identifying age, comorbidities, and immune cell types associated with altered expression.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

A 573 bp insertion in the YFT1 gene's 5' UTR disrupts ethylene signaling and carotenoid synthesis, causing yellow fruit in tomato mutants.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This paper introduces a multimodal imaging platform that combines nonlinear optical and thermal imaging to characterize biological tissues without labels.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

The paper presents a stochastic simulation platform that models transcriptional kinetics and estimates reaction rates using a Gillespie algorithm and single-cell RNA imaging data.

This paper reanalyzes CT scan data of Oculudentavis and concludes it is a squamate, not a bird or archosaur, based on morphological evidence.

The study identifies OsNLP4 as essential for nitrate assimilation gene expression and nitrate-dependent growth in rice.

The paper identifies two genes in Populus deltoides that antagonistically regulate sex determination by repressing female structures and promoting male structures through epigenetic and RNA-based mechanisms.

The paper introduces a novel DNA crosslinker, AP3B, which is significantly more effective than the commercial EZ-Link Psoralen-PEG3-Biotin in labeling DNA in cells and crosslinking DNA strands in vitro.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This study uses genomic data to estimate the origin and transmission dynamics of 2019-nCoV, finding the MRCA date and a decline in the effective reproductive number around January 2020.

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

The paper shows that B. subtilis mutants with quorum-sensing mutations produce antifungal ketones instead of surfactins when interacting with the fungus S. terrestris.

This study examines seasonal changes in soil microbial diversity and its relationship with soil chemical properties in a subtropical orchard.

This study identifies SUMOylation as a mechanism that stabilizes sister kinetochore biorientation by modulating Aurora B kinase and PP2A interactions.

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

PATTIE enables exploratory spatial-semantic information retrieval in biomedical literature through an interactive system and software tools.

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.