Q. Zhang

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

This study shows that Nintedanib prevents cardiac fibrosis and dysfunction in a mouse model of heart failure, even after treatment interruption.

This study shows that a Nrf2 activator improves mitochondrial function and proteostasis in aging guinea pigs but does not significantly enhance mobility.

This study identifies a lysosomal lipid signaling pathway from fat to neurons in C. elegans that promotes longevity by regulating neuropeptide signaling.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.

This study shows stress granules regulate immune responses to dsRNA by preventing excessive inflammation and viral replication.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

The paper defends the Bayesian Brownian Bridge method against criticism, showing its estimates of angiosperm clade ages are valid despite concerns about fossil data scarcity and sampling bias.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

This study uses transcriptomes and genome data to resolve phylogenetic relationships and detect whole-genome duplication in Theaceae, finding a WGD event and introgression events.

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

The paper introduces thiophosphopeptides that target the Golgi apparatus and selectively kill cancer cells through enzymatic self-assembly.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

The paper shows elevated Activin A and FLRG levels in COVID-19 patients predict severe outcomes like mechanical ventilation and mortality.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

This study uses neutron crystallography to show that inhibitor binding changes protonation states of three histidine residues in SARS-CoV-2 Mpro, providing insights for drug design.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This paper develops a kinetic model of DnaA regulation in E. coli to explain how cell size and cell cycle are coordinated, reproducing experimental results and predicting responses to perturbations.

This paper develops statistical tools for analyzing spatial rotations in 3D cryoEM using unit quaternions to enable comparisons, interpolations, and inference of rotations.