Q. Zhang

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study shows EsxA is internalized into host cells and inserts into host membranes, and surface-associated EsxAB enhances mycobacterial adherence and invasion.

This paper shows that BBS mice have impaired fear memory, which is partially rescued by lithium treatment.

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

This study determines the protonation states of SARS-CoV-2 main protease using neutron crystallography, revealing a zwitterionic active site with specific charge states of key residues.

This paper introduces statistical measures for spatial rotations and projection directions in cryoEM, accounting for molecular symmetry, and implements them in an open-source Python package.

This study identifies oxidative phosphorylation as a driver of treatment failure in recurrent HPV-related head and neck cancer, highlighting Nrf2 as a therapeutic target.

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

This study shows SARS-CoV-2 activates human plasmacytoid pre-dendritic cells (pDC) via UNC93B and IRAK4, leading to interferon and cytokine production.

The paper analyzes antibody repertoires against endemic human coronaviruses in children and adults, finding distinct epitope targets and cross-reactivity patterns.

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

This study shows that PALI1, a vertebrate-specific PRC2 accessory subunit, convergently evolved to function like JARID2 by allosterically activating PRC2 through methylation and DNA binding.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This paper presents a phylogenomic study of Brosimum and related genera, revealing their evolutionary relationships and proposing a revised subgeneric classification.

This study systematically analyzes ferroptosis in cancer using TCGA data, finding that ferroptosis-related genes are aberrantly expressed and that FPI is associated with prognosis and drug sensitivity.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

PM2RA detects and quantifies microbial relationship alterations between healthy and diseased states, showing higher specificity and sensitivity than co-occurrence-based methods.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

The paper develops a method to study hematopoietic stem cell clones and finds they have distinct transcriptional profiles and fate outcomes.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.