Q. Zhang

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study shows that Cdk11 promotes centromeric transcription to maintain cohesion during mitosis by phosphorylating RNAPII.

The paper shows that phosphatidic acid, produced by phospholipase Dδ, mediates the nuclear translocation of cytosolic GAPC under heat stress in plants.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study shows Mitoxantrone inhibits SARS-CoV-2 infection by targeting the spike-GAG complex, but also affects nucleosome dynamics.

The paper identifies a PHYB-PIF4-MYC2 module that regulates secondary cell wall thickening in Arabidopsis under shaded light conditions.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

The paper identifies nuclear factors that interact with the lipid chaperone LBP-8 in C. elegans, showing that nuclear import is required for LBP-8's longevity-promoting effects.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.