R. Chen

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

This paper evaluates a bivalent intranasal vaccine candidate combining SARS-CoV-2 N protein and ODN-39M, showing cross-reactive immunity against SARS-CoV-1 and enhanced Th1 response when combined with RBD.

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This paper shows that BET inhibition makes immunologically cold Rb-deficient prostate cancer more responsive to immune checkpoint blockade by reprogramming the tumor microenvironment through STING/NF-κB/IFN signaling.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

This study compares retinal organoid differentiation speed between rhesus macaque and human stem cells, finding NHP-derived organoids develop faster.

The paper uses super-resolution microscopy and a fluorescent probe to analyze lysosome spatial organization relative to mitochondria, revealing changes in distance distribution patterns during autophagy and linking lysosome positioning to mitochondrial health.

This study identifies Rmt5 as a critical regulator of Cryptococcus neoformans morphology and virulence by characterizing its interactome and phenotypic effects.

The paper identifies a rare antibody that targets the SARS-CoV-2 spike trimer interface, disrupting viral entry and providing protection in mice.

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

This study computes the affinity of AQP7 for glycerol using molecular dynamics simulations and finds a dissociation constant of approximately 0.18 mM.

This study identifies effector loss in Pseudomonas syringae pv. actinidiae as a driver of adaptation to Actinidia arguta, revealing key effectors involved in host resistance.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that the TFIIH complex is essential for maintaining mitotic chromosome structure in Xenopus egg extracts by facilitating condensin loading and loop extrusion.

The paper identifies Kin17 as a regulator of Miranda localization in Drosophila neuroblasts by promoting splicing of Falafel, a PP4 component, ensuring proper basal localization of Miranda during asymmetric division.

This study shows that e-cigarette aerosol increases cardiovascular oxidative stress in mice with the ALDH2*2 genetic variant, leading to higher ROS, protein damage, and NF-kB activation.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

The paper defines single-cell trajectories and identifies chromatin regulators that establish antiviral CD8 T cell heterogeneity during acute and chronic infections.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

The study finds that women in their fertility phase rate men with high serum testosterone as less attractive, challenging the ovulatory shift hypothesis.

This paper evaluates high-resolution atmospheric and oceanic simulations of the California Current System, showing good agreement with satellite and in situ measurements for physical fields and wind forcing impacts.