S. Sun

This study shows that nitric oxide inhibits gibberellin signaling by S-nitrosylating RGA, balancing growth and salt tolerance in Arabidopsis under salinity stress.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

SLDP1, SLDP2, and LIPA tether lipid droplets to the plasma membrane in Arabidopsis thaliana seedlings.

This study shows bisphosphonates inhibit the mevalonate pathway in macrophages, enhancing immune responses to bacterial endotoxin in the lung.

This study identifies microbiome alterations in microscopic colitis patients compared to controls, finding lower alpha-diversity and specific taxa associations in the descending colon.

This study identifies CFAP61 as essential for sperm flagellum formation and male fertility in humans and mice, showing its role in axoneme stabilization and its mutation causing infertility.

This study shows that LAT protein condensation on membranes is kinetically frustrated by limited bond availability, leading to dynamically arrested extended states rather than equilibrium compact domains.

The paper determines the near-atomic structure of the Saccharomyces cerevisiae nuclear pore complex inner ring, revealing its assembly and functional dynamics.

The paper presents cryo-EM structures of yeast TRAPPII complex in apo and Ypt32-bound states, revealing its assembly mechanism and specific activation of Ypt31/Ypt32.

This study shows that mechanical compression of muscle stem cells induces quiescence by altering tension and activating Notch signaling independently of canonical cleavage.

This study shows that endothelial cells self-organize into ring-like patterns on hydrogel microwells based on geometry and substrate stiffness, independent of chemical cues.

This study evaluates over 30 enzymes for glycoengineering immobilized IgG, demonstrating a solid-phase platform for efficient glycan remodeling and harmonization into complex-type N-glycoforms with high yield and retained binding affinity.

This study investigates how context conditioning affects the reinstatement of alcohol-seeking behavior in rats, finding that massed context extinction reduces reinstatement.

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study identifies cell cycle regulators involved in ploidy transitions during unisexual reproduction in C. deneoformans and reveals segmental aneuploidy associated with azole resistance.

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

This study identifies vitronectin-integrin signaling as a mechanism by which pericytes regulate blood-CNS barrier integrity through inhibition of transcytosis in endothelial cells.

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

The paper characterizes the step-wise acquisition of carboplatin resistance in ovarian cancer using single-cell gene expression analysis and identifies distinct transcriptional patterns associated with resistance.

This study compares the robustness of microbiota association inference using stool, swab, and mucosal tissue samples in a larger cohort, finding that mucosal samples yield less consistent results than stool or swab.

This study identifies novel regulatory modules involving ZmBEH1 and ZmBZR1 that control leaf angle in maize, offering new gene editing targets for improving plant architecture.

This study tracks the global spread of the carbapenem resistance gene blaNDM by analyzing genomic contexts and mobile genetic elements across 6000 bacterial genomes.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.