S. Sun

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

The paper discovers pseudosexual reproduction in Cryptococcus neoformans, where only one parental nucleus is inherited during bisexual mating, similar to hybridogenesis in animals.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The paper investigates the role of miR-129-5p in reversing CCl4-induced hepatic fibrosis by targeting PEG3 and the NF-κB pathway, though the manuscript has been withdrawn.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

The paper shows that limited inhibition of multiple core pathways in a driver network effectively blocks metastasis in mouse breast cancer models.

The paper shows signal sequences regulate protein translocation and folding in the ER by pausing translocation until chaperones bind, ensuring proper folding and preventing aggregation.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study shows that transposon mobilization in Cryptococcus deneoformans increases mutagenesis and drug resistance during infection and in vitro.

The paper identifies Sec63 as a regulator of IRE1α signaling attenuation during ER stress by recruiting BiP to inhibit IRE1 oligomerization and RNase activity.

The paper compares three glycoproteomic methods for analyzing N-linked glycosites in CHO cells treated with 1,3,4-O-Bu3ManNAc, finding that NGAG identifies more glycosites than SPEG and HILIC.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This paper introduces a BLSTM network to separate overlapping bat calls, achieving high separation quality and species classification accuracy.

This study identifies the role of C-terminal tails in guiding the assembly and degradation of membrane proteins in the ER.

CTRL measures single-cell volume dynamically using label-free deep learning and fluorescence exclusion from DIC images, revealing reduced cell size fluctuations during the cell cycle.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

The paper analyzes mating-type loci in Trichosporonales fungi, showing fused MAT loci with conserved gene order, supporting convergent evolution of linked mating-type regions.

This study evaluates immune responses in mice to multi-epitope DNA and protein vaccines against CCHFV, finding that DNA prime-protein boost strategy enhances both cellular and humoral immunity.

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.

The paper identifies genome-wide SNPs and InDels in four Actinidia arguta genotypes using whole-genome re-sequencing and links them to functional genes involved in stress responses and hormone signaling.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This study uses genomic analysis to identify three genetically distinct species within the Cryptococcus amylolentus complex, revealing chromosomal rearrangements and reproductive barriers.

This study identifies YAP/TAZ as regulators of single-cell volume, showing their role extends beyond cell cycle duration and shape, and they influence division volume independently of mTOR.

This study investigates the effects of fasting caecotrophy on growth performance and lipid metabolism in rabbits using RNA-Seq, finding reduced body weight, lipid droplet accumulation, and altered gene expression related to lipid metabolism.

This study examines how different stocking densities affect the liver proteome and cecal microbiota of Peking ducks, revealing oxidative stress and inflammation trends in high-density groups.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

This study establishes a glycoproteomic workflow to analyze N-linked glycosylation in CHO-K1 cells expressing EPO, identifying 10,338 glycopeptides and revealing atypical glycosylation sites.