S. Wang

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This study investigates how anionic amino acids in Dispersin B affect PNAG substrate recognition and hydrolysis, showing that D147 enhances catalytic activity with cationic PNAG.

This paper introduces BO-CNN, a neural network that detects cell death in live microscopy with 96% accuracy, faster than previous methods and without requiring stains or dyes.

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

The paper investigates how a mutation in Staphylococcus aureus dihydrofolate reductase affects antifolate resistance and NADPH isomerism through chiral evasion mechanisms.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

This study shows luteolin alters BMDM polarization by modulating STAT1/6 pathways, reducing pro-inflammatory factors and increasing anti-inflammatory ones.

This study shows PKCε is required for KRAS-driven lung tumorigenesis and identifies it as a potential therapeutic target.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

This paper introduces a method to site-specifically incorporate citrulline into proteins in mammalian cells and demonstrates its utility by showing reduced activity of modified PAD4 variants.

This study shows IGPR-1 activates AMPK, linking cell adhesion to autophagy through phosphorylation of ULK1 and Beclin-1, and identifies IKKβ as a key kinase in this pathway.

This study reconstructs the three-dimensional vasculature of Anaxagorea carpels, finding a radiosymmetrical pattern consistent with the Unifying Theory of carpel origin.

The paper identifies three microbial life strategies in soil that respond differently to snowmelt, influencing nitrogen availability during and after winter.

This study shows that EphA2 overexpression in NSCLC tumors reduces T cell infiltration and increases myeloid suppressor cells, promoting immune evasion.