S. Wang

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study investigates the preventive and therapeutic effects of R-salbutamol, S-salbutamol, and their racemic mixture in a mouse model of LPS-induced sepsis, finding R-salbutamol improves survival and lung function while S-salbutamol worsens outcomes.

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.

This study shows that FliW and CsrA regulate flagellin (FliC) synthesis in C. difficile R20291, affecting virulence and physiology through a mechanism similar to the 'FliW-CsrA-Hag' switch in B. subtilis.

This study determines the structure of DWORF and shows that a kink caused by Pro15 enables its unique activation of SERCA.

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

This study measures contractile ring tension in fission yeast and identifies Myo2 and Myp2 as key contributors to force generation and ring organization.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

The paper introduces EEIH, a method using hypertonicity to induce endosomal explosion for improved chitosan-mediated DNA delivery.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This paper introduces a framework to quantify both aggregate and compositional variability in metacommunities across space and time, identifying four scenarios based on spatial synchrony.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

This study uses multiplexed 3D imaging and machine learning to analyze colorectal cancer morphology and immune interactions, revealing molecular gradients and cell state transitions.

The paper identifies an allele of WRR4A in Arabidopsis that confers resistance to a virulent isolate of Albugo candida but reduces resistance to other effectors.

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

The paper observes actomyosin contractile instability in isolated cytokinetic rings and shows myosin II turnover prevents catastrophic aggregation and fracture.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study uses PTR-TOF-MS to analyze microbial volatile compounds during simulated snowmelt, revealing metabolic responses and interactions in soil microbiomes.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

The paper presents an AI method to predict SARS-CoV-2 variant binding affinity trends using atomistic simulations with high accuracy and reduced simulation time.

The paper analyzes metagenomic data from microbial communities to identify strategies underlying xenobiotic degradation and their ecological interactions.

This study develops and evaluates two multi-epitope vaccines against H. pylori using computer-aided design, showing they reduce bacterial colonization and stomach damage in infected mice.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.