W. Li

This paper develops and validates a high-throughput system for long-term optical measurement of peri-cellular oxygen in cardiac cells, showing dynamic oxygen changes and differences between hiPSC-CMs and fibroblasts.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

This study shows that ATP6AP2 downregulation in senescent breast cancer cells causes pH dysregulation, impairing lysosome function and altering immune responses.

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

The paper develops a scaling theory for polymer brushes inspired by ribosomal RNA transcription, showing how polymerization rate affects monomer diffusion and volume fraction.

This study identifies Cry2's role in adipogenesis through its interaction with Per2, showing that repression of Wnt signaling promotes adipocyte development.

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

The paper analyzes TAD boundaries across species to show evolutionary conservation and functional significance, finding ultraconserved boundaries have stronger insulation and CTCF binding.

This study shows BCAT1 inhibition alters iron homeostasis, affecting CD8+ T cell activation, exhaustion, and tumor immunity, with potential as a cancer therapy.

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

This study shows Nobiletin suppresses adipogenesis by enhancing the circadian clock and activating Wnt signaling, leading to reduced fat mass and body weight in mice.

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

The paper uses single-molecule displacement mapping to show small solutes diffuse freely in cells, with high diffusivity regions and localized slowdowns.

The paper uses single-molecule displacement mapping to show that positive charges impede protein diffusion in organelles, while negative charges do not, with an exception in the ER protein PPIB.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study identifies conserved roles of dynein intermediate chain and Ndel1 in dynein-dynactin-adapter complex assembly and activation through structural and functional analyses.

This study identifies iTie as a regulator of intestinal tolerance by suppressing the NLRP6 inflammasome, with implications for treating bowel diseases.

This study demonstrates that trisomy of chromosome 1q is essential for malignant growth in cancers and shows that TP53 mutations are mutually exclusive with 1q aneuploidy.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

The paper reanalyzes existing data to show cross-kingdom RNAi between Botrytis cinerea and tomato, contradicting a previous study.

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

This paper introduces an inhomogeneous mathematical model based on the generalized logistic equation to describe tumor growth and treatment, validated against clinical observations and theories of tumor heterogeneity.

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

The paper isolates and characterizes a novel lytic vibriophage, R16F, which shows potential as a biocontrol agent against V. parahaemolyticus due to its specificity and lack of virulence factors.