W. Wang

The paper investigates the origin of the SARS-CoV-2 Omicron variant, finding evidence suggesting it jumped from humans to mice and then back to humans.

This study shows DRP1 clusters at mitochondria-SR contact sites via β-actin, maintaining mitochondrial quality control in adult hearts despite reduced DRP1 levels.

This paper introduces a method using nanomechanical resonators to measure AAV vector mass with high precision, enabling real-time quality control in biomanufacturing.

This study evaluates the neutralization resistance and spike protein properties of SARS-CoV-2 B.1.617 variants, finding modest resistance to sera and therapeutic antibodies, but enhanced cleavage and fusogenic activity in Delta variants.

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

This study shows weakly migratory breast cancer cells use microvesicle-Tg2 to activate fibroblasts, promoting metastasis through tumor stiffening and fibroblast activation.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

The paper uses single-cell ATAC and RNA sequencing to identify pre-existing and treatment-persistent stem-like cell subpopulations in prostate cancer models that predict treatment response.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study examines how resetting affects the ergodicity and mean-squared displacements in fractional Brownian motion and heterogeneous diffusion processes, revealing nonergodicity and nonmonotonicity in the ergodicity breaking parameter.

This paper introduces RPnet, a neural network method for coarse-graining metastable conformational states in protein dynamics, showing comparable or better results than existing methods.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

The paper identifies RYR1 as a key channel regulating sweet and umami perception in rats through Ca2+ dynamics and proposes a metabolic clock model.

The paper calculates folding thermodynamics of WW domain variants using simulations and predicts effects of guanidine hydrochloride concentration changes.

The paper evaluates resistance of 25 therapeutic antibodies to SARS-CoV-2 variants with multiple spike substitutions, finding key substitutions predict resistance but other substitutions can modify it unpredictably.

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

The paper investigates how inertia affects the ergodic properties of fractional Brownian motion, showing that it changes the ergodicity breaking parameter and the equivalence between ensemble- and time-averaged MSDs.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.