W. Wang

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

DrugComb updates its repository and analysis tools to include more comprehensive drug combination and monotherapy data, enhanced algorithms, network modeling, and machine learning models for predicting drug sensitivity and synergy.

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

The paper characterizes the subunit composition and structure of native adult glycine receptors, showing a 4:1 stoichiometry of 2 and β subunits and their functional implications.

The paper identifies cold resistance in a nematode population and finds genetic and transcriptional differences between temperate and tropical strains.

This study evaluates variant calling tools for detecting minority variants in viral sequencing data and provides guidance for accurate quantification of intrahost viral diversity.

This study identifies four residues in Lassa virus GP1 critical for receptor switch to LAMP1, showing their impact on binding affinity and infectivity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study shows that hydroxychloroquine increases anxiety and depressive behaviors and alters gene expression in mouse brains, suggesting potential mental health risks.

This study identifies PcDHCR7 in Phytophthora capsici as a {bigtriangleup}7-sterol reductase essential for mycelium development and pathogenicity.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

The paper presents a method to identify Markov model topologies for ion channel dynamics using experimental data from two types of voltage-gated ion channels.

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

This paper shows that lipoylated H-protein can catalyze glycine cleavage and synthesis reactions in vitro without the other GCS proteins.

The paper develops an electrochemical immunosensor for detecting azocyclotin residues using Co3O4/PAn nanoparticles, achieving good sensitivity and accuracy in agricultural samples.

This study identifies biomarkers and candidate regulators in multiple myeloma under AURKA knockout using bioinformatics analysis of gene expression data.

This study shows that combining DNMT and NAMPT inhibitors with platinum reduces OCSCs and tumorigenesis in ovarian cancer.

The paper identifies a noncanonical mRNA decay process, RIDDLE, mediated by IRE1α oligomers in cancer cells, which promotes survival by degrading mRNAs without XBP1-like endomotifs.

This study uses rational protein engineering to enhance cold activity in a thermophilic lipase without compromising thermostability.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study evaluates how N-linked glycans on Lassa virus GPC affect immune response, finding that glycan deletion enhances effector T cell proportions and antibody titers, suggesting potential for vaccine design.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.